Assay Detail
Functional
CHEMBL784302
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Increased acid secretion in the isolated whole rat stomach
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Stomach |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Phthalazine PDE4 inhibitors. Part 2: the synthesis and biological evaluation of 6-methoxy-1,4-disubstituted derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.70 | 6.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL511115 | CILOMILAST | 3.0 | 1 | 6.00 |
| CHEMBL310387 | — | — | 1 | 5.40 |
| CHEMBL81364 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL511115 | CILOMILAST | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL310387 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL81364 | — | IC50 | > | 30000.0 | nM | - |