Assay Detail
Functional
CHEMBL784304
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Ability to inhibit [3H]dopamine uptake was measured in a chopped tissue assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and biological evaluation of 2-substituted 3beta-tolyltropane derivatives at dopamine, serotonin, and norepinephrine transporters.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.87 | 7.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL19944 | — | — | 1 | 7.80 |
| CHEMBL279074 | — | — | 1 | 7.09 |
| CHEMBL19715 | — | — | 1 | 6.58 |
| CHEMBL276332 | — | — | 1 | 6.51 |
| CHEMBL370805 | COCAINE | 4.0 | 1 | 6.39 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL19944 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL279074 | — | IC50 | = | 82.0 | nM | 7.09 |
| CHEMBL19715 | — | IC50 | = | 266.0 | nM | 6.58 |
| CHEMBL276332 | — | IC50 | = | 311.0 | nM | 6.51 |
| CHEMBL370805 | COCAINE | IC50 | = | 405.0 | nM | 6.39 |