Assay Detail
Functional
CHEMBL784317
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Inhibitory activity against nAChR mediated nicotine-evoked [3H]DA overflow using rat striatal slices
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Subtype-selective nicotinic receptor antagonists: potential as tobacco use cessation agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.71 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL54331 | — | — | 1 | 8.30 |
| CHEMBL55181 | — | — | 1 | 7.52 |
| CHEMBL55006 | — | — | 1 | 7.52 |
| CHEMBL416496 | — | — | 1 | 6.52 |
| CHEMBL52918 | — | — | 1 | 6.21 |
| CHEMBL55795 | — | — | 1 | 6.00 |
| CHEMBL53780 | — | — | 1 | 5.82 |
| CHEMBL54117 | — | — | 1 | 5.78 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL54331 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL55181 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL55006 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL416496 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL52918 | — | IC50 | = | 610.0 | nM | 6.21 |
| CHEMBL55795 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL53780 | — | IC50 | = | 1520.0 | nM | 5.82 |
| CHEMBL54117 | — | IC50 | = | 1660.0 | nM | 5.78 |