Assay Detail
Functional
CHEMBL784328
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was evaluated for its ability to block the [3H]-Dopamine uptake in rat caudate-putamen
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Caudate-putamen |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Novel 3 alpha-(diphenylmethoxy)tropane analogs: potent dopamine uptake inhibitors without cocaine-like behavioral profiles.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 6.65 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL281594 | VANOXERINE | 3.0 | 1 | 8.30 |
| CHEMBL543113 | — | — | 1 | 7.15 |
| CHEMBL541825 | — | — | 1 | 7.12 |
| CHEMBL3085569 | — | — | 1 | 6.94 |
| CHEMBL1201203 | BENZTROPINE | 4.0 | 1 | 6.39 |
| CHEMBL557818 | — | — | 1 | 6.33 |
| CHEMBL545227 | — | — | 1 | 5.54 |
| CHEMBL310310 | — | — | 1 | 5.45 |
| CHEMBL370805 | COCAINE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL281594 | VANOXERINE | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL543113 | — | IC50 | = | 71.0 | nM | 7.15 |
| CHEMBL541825 | — | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL3085569 | — | IC50 | = | 115.0 | nM | 6.94 |
| CHEMBL1201203 | BENZTROPINE | IC50 | = | 403.0 | nM | 6.39 |
| CHEMBL557818 | — | IC50 | = | 468.0 | nM | 6.33 |
| CHEMBL545227 | — | IC50 | = | 2876.0 | nM | 5.54 |
| CHEMBL310310 | — | IC50 | = | 3519.0 | nM | 5.45 |
| CHEMBL370805 | COCAINE | IC50 | = | 123254.0 | nM | - |