Assay Detail
Functional
CHEMBL784335
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was evaluated for its ability to inhibit uptake of [3H]-dopamine into rat caudate putamen tissue
8
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Caudate-putamen |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis, structure, dopamine transporter affinity, and dopamine uptake inhibition of 6-alkyl-3-benzyl-2-[(methoxycarbonyl)methyl]tropane derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.61 | 7.03 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL339395 | — | — | 1 | 7.03 |
| CHEMBL3085521 | — | — | 2 | 6.97 |
| CHEMBL136499 | — | — | 1 | 6.79 |
| CHEMBL545080 | — | — | 2 | 6.68 |
| CHEMBL1790051 | — | — | 1 | 6.43 |
| CHEMBL370805 | COCAINE | 4.0 | 1 | 6.39 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL339395 | — | IC50 | = | 94.0 | nM | 7.03 |
| CHEMBL3085521 | — | IC50 | = | 107.0 | nM | 6.97 |
| CHEMBL136499 | — | IC50 | = | 161.0 | nM | 6.79 |
| CHEMBL545080 | — | IC50 | = | 208.0 | nM | 6.68 |
| CHEMBL1790051 | — | IC50 | = | 373.0 | nM | 6.43 |
| CHEMBL370805 | COCAINE | IC50 | = | 405.0 | nM | 6.39 |
| CHEMBL545080 | — | IC50 | = | 457.0 | nM | 6.34 |
| CHEMBL3085521 | — | IC50 | = | 532.0 | nM | 6.27 |