Assay Detail
Functional
CHEMBL784340
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The inhibitory concentration (IC50) for vasorelaxation on rat aorta
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Aorta |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Recent developments in the biology and medicinal chemistry of potassium channel modulators: update from a decade of progress.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.09 | 7.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL11684 | (-)-CROMAKALIM | — | 1 | 7.50 |
| CHEMBL44340 | — | — | 1 | 5.75 |
| CHEMBL289133 | — | — | 1 | 5.03 |
| CHEMBL11594 | BMS-191095 | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL11684 | (-)-CROMAKALIM | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL44340 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL289133 | — | IC50 | = | 9400.0 | nM | 5.03 |
| CHEMBL11594 | BMS-191095 | IC50 | > | 30000.0 | nM | - |