Assay Detail
Functional
CHEMBL784392
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antihypertensive activity when administered orally to spontaneously hypertensive rats
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Dihydropyrimidine calcium channel blockers. 3. 3-Carbamoyl-4-aryl-1,2,3,4-tetrahydro-6-methyl-5-pyrimidinecarboxylic acid esters as orally effective antihypertensive agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 7.31 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL354009 | — | — | 1 | 8.70 |
| CHEMBL1491 | AMLODIPINE | 4.0 | 1 | 8.60 |
| CHEMBL193 | NIFEDIPINE | 4.0 | 1 | 8.60 |
| CHEMBL165592 | — | — | 1 | 8.52 |
| CHEMBL1907941 | — | — | 1 | 8.07 |
| CHEMBL273934 | — | — | 1 | 7.92 |
| CHEMBL166502 | — | — | 1 | 7.89 |
| CHEMBL353405 | — | — | 1 | 7.80 |
| CHEMBL167855 | — | — | 1 | 7.70 |
| CHEMBL167083 | — | — | 1 | 7.51 |
| CHEMBL353077 | — | — | 1 | 7.47 |
| CHEMBL355491 | — | — | 1 | 7.41 |
| CHEMBL354963 | — | — | 1 | 7.40 |
| CHEMBL166590 | — | — | 1 | 7.37 |
| CHEMBL167490 | — | — | 1 | 7.36 |
| CHEMBL167381 | — | — | 1 | 7.26 |
| CHEMBL166379 | — | — | 1 | 7.22 |
| CHEMBL352530 | — | — | 1 | 7.09 |
| CHEMBL167072 | — | — | 1 | 7.08 |
| CHEMBL352855 | — | — | 1 | 6.06 |
| CHEMBL167975 | — | — | 1 | 5.80 |
| CHEMBL424356 | — | — | 1 | 5.78 |
| CHEMBL167976 | — | — | 1 | 5.50 |
| CHEMBL2093056 | — | — | 1 | 5.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL354009 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL1491 | AMLODIPINE | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL193 | NIFEDIPINE | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL165592 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL1907941 | — | IC50 | = | 8.5 | nM | 8.07 |
| CHEMBL273934 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL166502 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL353405 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL167855 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL167083 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL353077 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL355491 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL354963 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL166590 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL167490 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL167381 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL166379 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL352530 | — | IC50 | = | 82.0 | nM | 7.09 |
| CHEMBL167072 | — | IC50 | = | 83.0 | nM | 7.08 |
| CHEMBL352855 | — | IC50 | = | 880.0 | nM | 6.06 |
| CHEMBL167975 | — | IC50 | = | 1580.0 | nM | 5.80 |
| CHEMBL424356 | — | IC50 | = | 1670.0 | nM | 5.78 |
| CHEMBL167976 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL2093056 | — | IC50 | = | 3790.0 | nM | 5.42 |