Assay Detail
Functional
CHEMBL784402
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
89
Total Activities
87
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Oryctolagus cuniculus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Target
Platelet-activating factor receptor (CHEMBL5136) ↗| Type | SINGLE PROTEIN |
| Organism | Cavia porcellus |
Publication
Disubstituted tetrahydrofurans and dioxolanes and PAF antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 89 | 6.36 | 8.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL128034 | — | — | 1 | 8.35 |
| CHEMBL126016 | — | — | 1 | 8.17 |
| CHEMBL127419 | — | — | 1 | 8.12 |
| CHEMBL125576 | — | — | 1 | 8.10 |
| CHEMBL126981 | — | — | 1 | 8.09 |
| CHEMBL419779 | — | — | 1 | 8.07 |
| CHEMBL124534 | — | — | 2 | 7.96 |
| CHEMBL113603 | — | — | 1 | 7.96 |
| CHEMBL274420 | CV-6209 | — | 1 | 7.92 |
| CHEMBL127678 | — | — | 1 | 7.85 |
| CHEMBL126958 | — | — | 1 | 7.82 |
| CHEMBL127266 | — | — | 1 | 7.82 |
| CHEMBL126302 | — | — | 1 | 7.75 |
| CHEMBL338441 | — | — | 1 | 7.72 |
| CHEMBL123570 | — | — | 1 | 7.62 |
| CHEMBL125411 | — | — | 1 | 7.58 |
| CHEMBL338345 | — | — | 1 | 7.57 |
| CHEMBL124906 | — | — | 1 | 7.48 |
| CHEMBL124985 | — | — | 1 | 7.28 |
| CHEMBL338519 | — | — | 1 | 7.15 |
| CHEMBL124394 | — | — | 1 | 7.14 |
| CHEMBL338368 | — | — | 1 | 7.14 |
| CHEMBL421618 | — | — | 1 | 7.10 |
| CHEMBL340247 | — | — | 1 | 7.08 |
| CHEMBL127010 | — | — | 1 | 7.07 |
| CHEMBL127887 | — | — | 1 | 7.03 |
| CHEMBL125080 | — | — | 1 | 7.00 |
| CHEMBL125465 | — | — | 1 | 6.96 |
| CHEMBL127324 | — | — | 1 | 6.85 |
| CHEMBL125412 | — | — | 1 | 6.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL128034 | — | IC50 | = | 4.5 | nM | 8.35 |
| CHEMBL126016 | — | IC50 | = | 6.8 | nM | 8.17 |
| CHEMBL127419 | — | IC50 | = | 7.5 | nM | 8.12 |
| CHEMBL125576 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL126981 | — | IC50 | = | 8.2 | nM | 8.09 |
| CHEMBL419779 | — | IC50 | = | 8.6 | nM | 8.07 |
| CHEMBL124534 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL113603 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL274420 | CV-6209 | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL127678 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL126958 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL127266 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL126302 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL338441 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL124534 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL123570 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL125411 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL338345 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL124906 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL124985 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL338519 | — | IC50 | = | 71.0 | nM | 7.15 |
| CHEMBL124394 | — | IC50 | = | 72.0 | nM | 7.14 |
| CHEMBL338368 | — | IC50 | = | 73.0 | nM | 7.14 |
| CHEMBL421618 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL340247 | — | IC50 | = | 83.0 | nM | 7.08 |
| CHEMBL127010 | — | IC50 | = | 85.0 | nM | 7.07 |
| CHEMBL127887 | — | IC50 | = | 94.0 | nM | 7.03 |
| CHEMBL125080 | — | IC50 | = | 99.0 | nM | 7.00 |
| CHEMBL125465 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL127324 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL125412 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL127890 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL124071 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL338689 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL125903 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL338977 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL125078 | — | IC50 | = | 830.0 | nM | 6.08 |
| CHEMBL124562 | — | IC50 | = | 860.0 | nM | 6.07 |
| CHEMBL127746 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL125419 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL340489 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL14604 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL127875 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL338476 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL126524 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL127766 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL340164 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL127704 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL338828 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL124523 | — | IC50 | = | 1700.0 | nM | 5.77 |