Assay Detail
Functional
CHEMBL784403
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Inhibitory activity for 5-HT uptake was determined using [3H]- Citalopram
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Novel and highly potent 5-HT3 receptor agonists based on a pyrroloquinoxaline structure.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.51 | 6.69 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL18772 | QUIPAZINE | 2.0 | 1 | 6.69 |
| CHEMBL120216 | — | — | 1 | 6.69 |
| CHEMBL327197 | — | — | 1 | 6.67 |
| CHEMBL341474 | — | — | 1 | 6.63 |
| CHEMBL39 | SEROTONIN | 3.0 | 1 | 6.43 |
| CHEMBL331304 | — | — | 1 | 5.95 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL18772 | QUIPAZINE | IC50 | = | 204.0 | nM | 6.69 |
| CHEMBL120216 | — | IC50 | = | 203.0 | nM | 6.69 |
| CHEMBL327197 | — | IC50 | = | 214.0 | nM | 6.67 |
| CHEMBL341474 | — | IC50 | = | 232.0 | nM | 6.63 |
| CHEMBL39 | SEROTONIN | IC50 | = | 369.0 | nM | 6.43 |
| CHEMBL331304 | — | IC50 | = | 1129.0 | nM | 5.95 |