Assay Detail
Functional
CHEMBL784457
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Compound was evaluated for prevention of spontaneous lipid peroxidation in rat brain homogenate.
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
A cardioselective, hydrophilic N,N,N-trimethylethanaminium alpha-tocopherol analogue that reduces myocardial infarct size.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.48 | 6.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL87570 | — | — | 1 | 6.30 |
| CHEMBL86847 | — | — | 1 | 5.77 |
| CHEMBL47 | ALPHA-TOCOPHEROL | — | 1 | 4.92 |
| CHEMBL153 | TROLOX | — | 1 | 4.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL87570 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL86847 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL47 | ALPHA-TOCOPHEROL | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL153 | TROLOX | IC50 | = | 12000.0 | nM | 4.92 |