Assay Detail
Functional
CHEMBL784481
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Serum concentration for 50% inhibition of uterine contractility response to oxytocin in rat
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Identification of potent and selective oxytocin antagonists. Part 2: further investigation of benzofuran derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.67 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL31065 | — | — | 1 | 7.70 |
| CHEMBL284442 | — | — | 1 | 7.70 |
| CHEMBL24781 | — | — | 1 | 7.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL31065 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL284442 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL24781 | — | IC50 | = | 25.0 | nM | 7.60 |