Assay Detail
Functional
CHEMBL784807
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Effective concentration was measured for the release of accumulated [3H]NE from chopped cortex of rat
10
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Pronounced pharmacological differences arising from minor structural changes in conformationally defined amphetamine analogues. Comparative evaluation of endo- and exo-2-amino- and endo- and exo-2-(methylamino)benzobicyclo[2.2.1]heptene and -benzobicylco[2.2.2]octene analogues. Conformationally defined adrenergic agents. 4.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 10 | 5.56 | 6.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL612 | DEXTROAMPHETAMINE | 4.0 | 1 | 6.10 |
| CHEMBL19393 | LEVAMFETAMINE | 4.0 | 1 | 5.77 |
| CHEMBL49263 | — | — | 1 | 4.80 |
| CHEMBL157518 | — | — | 2 | - |
| CHEMBL301289 | — | — | 1 | - |
| CHEMBL154758 | — | — | 2 | - |
| CHEMBL157748 | — | — | 2 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL612 | DEXTROAMPHETAMINE | EC50 | = | 800.0 | nM | 6.10 |
| CHEMBL19393 | LEVAMFETAMINE | EC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL49263 | — | EC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL157518 | — | EC50 | = | 1000000.0 | nM | - |
| CHEMBL301289 | — | EC50 | = | 630000.0 | nM | - |
| CHEMBL154758 | — | EC50 | = | 450000.0 | nM | - |
| CHEMBL157748 | — | EC50 | > | 1000000.0 | nM | - |
| CHEMBL154758 | — | EC50 | > | 1000000.0 | nM | - |
| CHEMBL157748 | — | EC50 | = | 178000.0 | nM | - |
| CHEMBL157518 | — | EC50 | = | 147000.0 | nM | - |