Assay Detail
Functional
CHEMBL784809
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Evaluated for effective concentration in, in vitro electrophysiological model in the rat cortical slice model.
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and pharmacology of N-alkylated derivatives of the excitotoxin ibotenic acid.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 4.97 | 5.02 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL284895 | — | — | 1 | 5.02 |
| CHEMBL280585 | — | — | 1 | 4.92 |
| CHEMBL287785 | — | — | 1 | - |
| CHEMBL41352 | — | — | 1 | - |
| CHEMBL287737 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL284895 | — | EC50 | = | 9600.0 | nM | 5.02 |
| CHEMBL280585 | — | EC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL287785 | — | EC50 | > | 1000000.0 | nM | - |
| CHEMBL41352 | — | EC50 | = | 140000.0 | nM | - |
| CHEMBL287737 | — | EC50 | = | 320000.0 | nM | - |