Assay Detail
Functional
CHEMBL785004
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In vitro inhibition of [3H]5-HT uptake in rat brain (minus pons, medulla oblongata and cerebellum) homogenates.
18
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Cerebellum |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Enhanced D1 affinity in a series of piperazine ring substituted 1-piperazino-3-arylindans with potential atypical antipsychotic activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 5.46 | 6.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL307717 | — | — | 2 | 6.21 |
| CHEMBL136683 | — | — | 2 | 5.75 |
| CHEMBL343922 | — | — | 1 | 5.75 |
| CHEMBL343282 | — | — | 2 | 5.70 |
| CHEMBL136822 | — | — | 1 | 5.62 |
| CHEMBL136260 | — | — | 2 | 5.58 |
| CHEMBL136235 | — | — | 2 | 5.43 |
| CHEMBL137960 | — | — | 2 | 5.40 |
| CHEMBL136722 | — | — | 2 | 5.28 |
| CHEMBL136630 | — | — | 2 | 5.14 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL307717 | — | IC50 | = | 610.0 | nM | 6.21 |
| CHEMBL343922 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL136683 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL343282 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL136822 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL136260 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL136260 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL136235 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL307717 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL137960 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL343282 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL137960 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL136722 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL136630 | — | IC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL136722 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL136235 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL136630 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL136683 | — | IC50 | > | 100.0 | nM | - |