Assay Detail
Functional
CHEMBL785041
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Compound was tested for 50% inhibition of cholesterol synthesis in isolated rat hepatocytes.
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Cell Type | Hepatocyte |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Phosphorus-containing inhibitors of HMG-CoA reductase. 1. 4-[(2-arylethyl)hydroxyphosphinyl]-3-hydroxy-butanoic acids: a new class of cell-selective inhibitors of cholesterol biosynthesis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.86 | 7.07 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL98469 | — | — | 1 | 7.07 |
| CHEMBL101621 | — | — | 1 | 7.03 |
| CHEMBL690 | PRAVASTATIN SODIUM | 4.0 | 1 | 7.00 |
| CHEMBL175236 | — | — | 1 | 6.84 |
| CHEMBL318784 | — | — | 1 | 6.61 |
| CHEMBL101721 | — | — | 1 | 6.58 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL98469 | — | IC50 | = | 85.0 | nM | 7.07 |
| CHEMBL101621 | — | IC50 | = | 93.0 | nM | 7.03 |
| CHEMBL690 | PRAVASTATIN SODIUM | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL175236 | — | IC50 | = | 146.0 | nM | 6.84 |
| CHEMBL318784 | — | IC50 | = | 245.0 | nM | 6.61 |
| CHEMBL101721 | — | IC50 | = | 260.0 | nM | 6.58 |