Assay Detail
Functional
CHEMBL785073
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro relaxation of rat aorta precontracted with methoxamine.
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Aorta |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Cardioselective antiischemic ATP-sensitive potassium channel (K(ATP)) openers. 6. Effect of modifications at C6 of benzopyranyl cyanoguanidines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 5.39 | 7.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL49035 | CROMAKALIM | 2.0 | 1 | 7.50 |
| CHEMBL122130 | — | — | 1 | 6.30 |
| CHEMBL122090 | — | — | 1 | 6.30 |
| CHEMBL433185 | — | — | 1 | 5.96 |
| CHEMBL44340 | — | — | 1 | 5.75 |
| CHEMBL123067 | — | — | 1 | 5.72 |
| CHEMBL122201 | — | — | 1 | 5.51 |
| CHEMBL126065 | — | — | 1 | 5.48 |
| CHEMBL123452 | — | — | 1 | 5.27 |
| CHEMBL333645 | — | — | 1 | 5.17 |
| CHEMBL122596 | — | — | 1 | 5.15 |
| CHEMBL122378 | — | — | 1 | 5.06 |
| CHEMBL289133 | — | — | 1 | 5.03 |
| CHEMBL340451 | — | — | 1 | 5.00 |
| CHEMBL331286 | — | — | 1 | 4.97 |
| CHEMBL122907 | — | — | 1 | 4.93 |
| CHEMBL340395 | — | — | 1 | 4.49 |
| CHEMBL124499 | — | — | 1 | 4.38 |
| CHEMBL262365 | — | — | 1 | 4.36 |
| CHEMBL122732 | — | — | 1 | - |
| CHEMBL11594 | BMS-191095 | — | 1 | - |
| CHEMBL123335 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL49035 | CROMAKALIM | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL122130 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL122090 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL433185 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL44340 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL123067 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL122201 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL126065 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL123452 | — | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL333645 | — | IC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL122596 | — | IC50 | = | 7100.0 | nM | 5.15 |
| CHEMBL122378 | — | IC50 | = | 8800.0 | nM | 5.06 |
| CHEMBL289133 | — | IC50 | = | 9400.0 | nM | 5.03 |
| CHEMBL340451 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL331286 | — | IC50 | = | 10700.0 | nM | 4.97 |
| CHEMBL122907 | — | IC50 | = | 11700.0 | nM | 4.93 |
| CHEMBL340395 | — | IC50 | = | 32100.0 | nM | 4.49 |
| CHEMBL124499 | — | IC50 | = | 41300.0 | nM | 4.38 |
| CHEMBL262365 | — | IC50 | = | 44100.0 | nM | 4.36 |
| CHEMBL122732 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL11594 | BMS-191095 | IC50 | > | 30000.0 | nM | - |
| CHEMBL123335 | — | IC50 | > | 30000.0 | nM | - |