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Assay Detail

CHEMBL785165

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Vasorelaxant potency determined by inhibition of methoxamine-contracted rat aorta
14
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Rattus norvegicus
Tissue Aorta
Confidence 1 — Organism
Curated By Intermediate

Target

Rattus norvegicus (CHEMBL376)
Type ORGANISM
Organism Rattus norvegicus

Publication

Cardioselective anti-ischemic ATP-sensitive potassium channel openers.
Atwal KS, Grover GJ, Ahmed SZ, Ferrara FN, Harper TW, Kim KS, Sleph PG, Dzwonczyk S, Russell AD, Moreland S.
J Med Chem (1993) 36 : 3971 -3974
PubMed 8254626 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 14 5.61 7.50

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL49035 CROMAKALIM 2.0 1 7.50
CHEMBL300166 1 6.10
CHEMBL58703 3 5.89
CHEMBL130028 1 5.85
CHEMBL126330 1 5.77
CHEMBL44340 1 5.75
CHEMBL336405 1 5.70
CHEMBL129743 1 5.66
CHEMBL340968 1 5.27
CHEMBL320930 1 5.09
CHEMBL320348 1 4.53
CHEMBL337827 1 4.14

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL49035 CROMAKALIM IC50 = 32.0 nM 7.50
CHEMBL300166 IC50 = 800.0 nM 6.10
CHEMBL58703 IC50 = 1300.0 nM 5.89
CHEMBL58703 IC50 = 1400.0 nM 5.85
CHEMBL130028 IC50 = 1400.0 nM 5.85
CHEMBL126330 IC50 = 1700.0 nM 5.77
CHEMBL44340 IC50 = 1800.0 nM 5.75
CHEMBL336405 IC50 = 2000.0 nM 5.70
CHEMBL129743 IC50 = 2200.0 nM 5.66
CHEMBL58703 IC50 = 4200.0 nM 5.38
CHEMBL340968 IC50 = 5400.0 nM 5.27
CHEMBL320930 IC50 = 8100.0 nM 5.09
CHEMBL320348 IC50 = 29800.0 nM 4.53
CHEMBL337827 IC50 = 72700.0 nM 4.14