Assay Detail
Functional
CHEMBL785170
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[3H]5-HT reuptake inhibition in Rat brain synaptosomes.
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
5-HT reuptake inhibitors with 5-HT(1B/1D) antagonistic activity: a new approach toward efficient antidepressants.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 7.65 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL276928 | — | — | 1 | 9.70 |
| CHEMBL15837 | — | — | 1 | 9.15 |
| CHEMBL279320 | — | — | 1 | 8.92 |
| CHEMBL15965 | — | — | 1 | 8.72 |
| CHEMBL430122 | — | — | 1 | 8.72 |
| CHEMBL15909 | — | — | 1 | 8.66 |
| CHEMBL280314 | — | — | 1 | 8.40 |
| CHEMBL280000 | — | — | 1 | 8.00 |
| CHEMBL2079627 | — | — | 1 | 7.68 |
| CHEMBL278917 | — | — | 1 | 7.31 |
| CHEMBL15961 | — | — | 1 | 7.19 |
| CHEMBL279646 | — | — | 1 | 6.97 |
| CHEMBL15855 | — | — | 1 | 6.70 |
| CHEMBL15139 | — | — | 1 | 6.50 |
| CHEMBL16035 | — | — | 1 | 6.41 |
| CHEMBL15808 | — | — | 1 | 6.33 |
| CHEMBL274922 | — | — | 1 | 6.33 |
| CHEMBL15928 | GR-127935 | — | 1 | 6.00 |
| CHEMBL15933 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL276928 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL15837 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL279320 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL15965 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL430122 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL15909 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL280314 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL280000 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL2079627 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL278917 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL15961 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL279646 | — | IC50 | = | 106.0 | nM | 6.97 |
| CHEMBL15855 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL15139 | — | IC50 | = | 314.0 | nM | 6.50 |
| CHEMBL16035 | — | IC50 | = | 387.0 | nM | 6.41 |
| CHEMBL15808 | — | IC50 | = | 469.0 | nM | 6.33 |
| CHEMBL274922 | — | IC50 | = | 472.0 | nM | 6.33 |
| CHEMBL15928 | GR-127935 | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL15933 | — | IC50 | > | 1000.0 | nM | - |