Assay Detail
Functional
CHEMBL785174
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tested for their ability to inhibit the after- hyperpolarization in cultured rat sympathetic neurons
8
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Cell Type | Sympathetic neuron |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
bis-Quinolinium cyclophanes: 8,14-diaza-1,7(1, 4)-diquinolinacyclotetradecaphane (UCL 1848), a highly potent and selective, nonpeptidic blocker of the apamin-sensitive Ca(2+)-activated K(+) channel.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 7.31 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL420873 | — | — | 1 | 8.70 |
| CHEMBL117908 | — | — | 1 | 8.52 |
| CHEMBL116191 | — | — | 1 | 7.40 |
| CHEMBL115457 | — | — | 1 | 7.22 |
| CHEMBL116260 | — | — | 2 | 6.89 |
| CHEMBL119859 | — | — | 1 | 6.72 |
| CHEMBL116403 | — | — | 1 | 6.58 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL420873 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL117908 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL116191 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL115457 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL116260 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL119859 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL116403 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL116260 | — | IC50 | = | 380.0 | nM | 6.42 |