Assay Detail
Functional
CHEMBL785220
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Tested for inhibition of NMDA-induced cyclic GMP increase in rat cerebellar slices
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
A unified approach to systematic isosteric substitution for acidic groups and application to NMDA antagonists related to 2-amino-7-phosphonoheptanoate.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 4.46 | 4.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL274440 | AP-7 | — | 1 | 4.46 |
| CHEMBL11393 | — | — | 1 | - |
| CHEMBL11665 | — | — | 1 | - |
| CHEMBL11605 | — | — | 1 | - |
| CHEMBL11664 | — | — | 1 | - |
| CHEMBL11599 | — | — | 1 | - |
| CHEMBL274216 | — | — | 1 | - |
| CHEMBL11666 | — | — | 1 | - |
| CHEMBL268483 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL274440 | AP-7 | IC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL11393 | — | IC50 | > | 10000000.0 | nM | - |
| CHEMBL11665 | — | IC50 | > | 10000000.0 | nM | - |
| CHEMBL11605 | — | IC50 | = | 220000.0 | nM | - |
| CHEMBL11664 | — | IC50 | = | 140000.0 | nM | - |
| CHEMBL11599 | — | IC50 | = | 260000.0 | nM | - |
| CHEMBL274216 | — | IC50 | = | 310000.0 | nM | - |
| CHEMBL11666 | — | IC50 | > | 10000000.0 | nM | - |
| CHEMBL268483 | — | IC50 | > | 10000000.0 | nM | - |