Assay Detail
Functional
CHEMBL785226
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity against the production of prostaglandin E2 (PGE2) in glycogen-induced peritoneal cells of rat
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Ovis aries |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Novel dual inhibitors of 5-lipoxygenase and thromboxane A2 synthetase: synthesis and structure-activity relationships of 3-pyridylmethyl-substituted 2-amino-6-hydroxybenzothiazole derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 5.14 | 5.26 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL321358 | — | — | 1 | 5.26 |
| CHEMBL322015 | — | — | 1 | 5.02 |
| CHEMBL320394 | — | — | 1 | - |
| CHEMBL3215733 | — | — | 1 | - |
| CHEMBL105386 | — | — | 1 | - |
| CHEMBL420281 | — | — | 1 | - |
| CHEMBL102243 | — | — | 1 | - |
| CHEMBL105587 | — | — | 1 | - |
| CHEMBL3217077 | — | — | 1 | - |
| CHEMBL3216177 | — | — | 1 | - |
| CHEMBL105139 | — | — | 1 | - |
| CHEMBL3216618 | — | — | 1 | - |
| CHEMBL3215555 | — | — | 1 | - |
| CHEMBL104156 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL321358 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL322015 | — | IC50 | = | 9600.0 | nM | 5.02 |
| CHEMBL320394 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3215733 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL105386 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL420281 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL102243 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL105587 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3217077 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3216177 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL105139 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3216618 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3215555 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL104156 | — | IC50 | > | 100000.0 | nM | - |