Assay Detail
Functional
CHEMBL788100
Review assay metadata, readout intent, target linkage, and publication context from the same page.
The compound was tested for its ability to inhibit AMPA-induced currents in rat brain mRNA-injected xenopus oocytes
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Phosphonoethylphenylalanine derivatives as novel antagonists of non-NMDA ionotropic glutamate receptors
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 4.49 | 4.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL23182 | — | — | 1 | 4.89 |
| CHEMBL284012 | — | — | 1 | 4.80 |
| CHEMBL281842 | — | — | 1 | 4.41 |
| CHEMBL23190 | — | — | 1 | 4.32 |
| CHEMBL23848 | — | — | 1 | 4.30 |
| CHEMBL22594 | — | — | 1 | 4.21 |
| CHEMBL280677 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL23182 | — | Ki | = | 13000.0 | nM | 4.89 |
| CHEMBL284012 | — | Ki | = | 16000.0 | nM | 4.80 |
| CHEMBL281842 | — | Ki | = | 39000.0 | nM | 4.41 |
| CHEMBL23190 | — | Ki | = | 48000.0 | nM | 4.32 |
| CHEMBL23848 | — | Ki | = | 50000.0 | nM | 4.30 |
| CHEMBL22594 | — | Ki | = | 61000.0 | nM | 4.21 |
| CHEMBL280677 | — | Ki | = | 167000.0 | nM | - |