Assay Detail
Functional
CHEMBL789197
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In vitro inhibitory activity of glycine (0.3 uM) responses in isolated cultured cortical neurons
5
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Derivatives of 1-hydroxy-3-aminopyrrolidin-2-one (HA-966). Partial agonists at the glycine site of the NMDA receptor
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 5.38 | 5.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL283819 | — | — | 1 | 5.89 |
| CHEMBL335231 | — | — | 2 | 5.60 |
| CHEMBL162442 | — | — | 1 | 4.81 |
| CHEMBL2115541 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL283819 | — | Ki | = | 1300.0 | nM | 5.89 |
| CHEMBL335231 | — | Ki | = | 2500.0 | nM | 5.60 |
| CHEMBL335231 | — | Ki | = | 6300.0 | nM | 5.20 |
| CHEMBL162442 | — | Ki | = | 15400.0 | nM | 4.81 |
| CHEMBL2115541 | — | Ki | > | 80000.0 | nM | - |