Assay Detail
Functional
CHEMBL789198
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In vitro inhibitory activity of glycine (0.3 uM) responses in isolated cultured cortical neurons
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Derivatives of 1-hydroxy-3-aminopyrrolidin-2-one (HA-966). Partial agonists at the glycine site of the NMDA receptor
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 5.49 | 6.12 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL131567 | — | — | 1 | 6.12 |
| CHEMBL337030 | — | — | 1 | 5.46 |
| CHEMBL165911 | — | — | 1 | 5.30 |
| CHEMBL2115569 | — | — | 1 | 5.09 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL131567 | — | Ki | = | 750.0 | nM | 6.12 |
| CHEMBL337030 | — | Ki | = | 3500.0 | nM | 5.46 |
| CHEMBL165911 | — | Ki | = | 5000.0 | nM | 5.30 |
| CHEMBL2115569 | — | Ki | = | 8200.0 | nM | 5.09 |