Assay Detail
Functional
CHEMBL789405
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Inhibition of adenosine stimulated accumulation of cyclic AMP at Adenosine A2 receptor of VA13 fibroblasts of rat
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Benzo[1,2-c:5,4-c']dipyrazoles: non-xanthine adenosine antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 5.74 | 6.17 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL157655 | — | — | 1 | 6.17 |
| CHEMBL286785 | — | — | 1 | 6.09 |
| CHEMBL416013 | — | — | 1 | 5.92 |
| CHEMBL1355736 | THEOPHYLLINE | 4.0 | 1 | 5.32 |
| CHEMBL1250 | 1-METHYLXANTHINE | — | 1 | 5.18 |
| CHEMBL1424 | XANTHINE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL157655 | — | Ki | = | 680.0 | nM | 6.17 |
| CHEMBL286785 | — | Ki | = | 820.0 | nM | 6.09 |
| CHEMBL416013 | — | Ki | = | 1200.0 | nM | 5.92 |
| CHEMBL1355736 | THEOPHYLLINE | Ki | = | 4800.0 | nM | 5.32 |
| CHEMBL1250 | 1-METHYLXANTHINE | Ki | = | 6600.0 | nM | 5.18 |
| CHEMBL1424 | XANTHINE | Ki | = | 130000.0 | nM | - |