Assay Detail
Functional
CHEMBL789407
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Inhibition of norepinephrine uptake into rat synaptosomes
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Duloxetine (Cymbalta), a dual inhibitor of serotonin and norepinephrine reuptake.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 7.43 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL641 | ATOMOXETINE | 4.0 | 1 | 8.40 |
| CHEMBL1175 | DULOXETINE | 4.0 | 1 | 7.80 |
| CHEMBL336920 | (R)-DULOXETINE | — | 1 | 7.80 |
| CHEMBL41 | FLUOXETINE | 4.0 | 1 | 5.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL641 | ATOMOXETINE | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL1175 | DULOXETINE | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL336920 | (R)-DULOXETINE | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL41 | FLUOXETINE | Ki | = | 2000.0 | nM | 5.70 |