Assay Detail
Functional
CHEMBL789409
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Inhibition was measured for [3H]GABA-uptake from rat synaptosomal membrane.
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis of alkyl-substituted arecoline derivatives as gamma-aminobutyric acid uptake inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 5.16 | 5.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL277498 | NIPECOTIC ACID | — | 1 | 5.42 |
| CHEMBL278575 | — | — | 1 | 4.89 |
| CHEMBL25301 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL277498 | NIPECOTIC ACID | Ki | = | 3800.0 | nM | 5.42 |
| CHEMBL278575 | — | Ki | = | 12900.0 | nM | 4.89 |
| CHEMBL25301 | — | Ki | = | 104000.0 | nM | - |