Assay Detail
Functional
CHEMBL791517
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity against 5-HT uptake site, using [3H]citalopram as radioligand in rat cortical membrane
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Iodinated tomoxetine derivatives as selective ligands for serotonin and norepinephrine uptake sites.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 13 | 8.44 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL553282 | — | — | 1 | 9.52 |
| CHEMBL545321 | — | — | 1 | 9.19 |
| CHEMBL545782 | — | — | 1 | 9.16 |
| CHEMBL556011 | — | — | 1 | 9.10 |
| CHEMBL542247 | — | — | 1 | 8.90 |
| CHEMBL545090 | — | — | 1 | 8.40 |
| CHEMBL545553 | — | — | 1 | 8.29 |
| CHEMBL539562 | — | — | 1 | 8.24 |
| CHEMBL553823 | — | — | 1 | 7.88 |
| CHEMBL541601 | — | — | 1 | 7.86 |
| CHEMBL541332 | — | — | 1 | 7.84 |
| CHEMBL545089 | — | — | 1 | 7.77 |
| CHEMBL1702 | ATOMOXETINE HYDROCHLORIDE | 4.0 | 1 | 7.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL553282 | — | Ki | = | 0.3 | nM | 9.52 |
| CHEMBL545321 | — | Ki | = | 0.65 | nM | 9.19 |
| CHEMBL545782 | — | Ki | = | 0.69 | nM | 9.16 |
| CHEMBL556011 | — | Ki | = | 0.8 | nM | 9.10 |
| CHEMBL542247 | — | Ki | = | 1.27 | nM | 8.90 |
| CHEMBL545090 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL545553 | — | Ki | = | 5.18 | nM | 8.29 |
| CHEMBL539562 | — | Ki | = | 5.73 | nM | 8.24 |
| CHEMBL553823 | — | Ki | = | 13.1 | nM | 7.88 |
| CHEMBL541601 | — | Ki | = | 13.9 | nM | 7.86 |
| CHEMBL541332 | — | Ki | = | 14.4 | nM | 7.84 |
| CHEMBL545089 | — | Ki | = | 17.1 | nM | 7.77 |
| CHEMBL1702 | ATOMOXETINE HYDROCHLORIDE | Ki | = | 25.1 | nM | 7.60 |