Assay Detail
Functional
CHEMBL795131
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Concentration required for GH release from isolated pituitary cells of rat tested in vitro
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Cell Type | Pituitary gland cell |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Highly potent growth hormone secretagogues: hybrids of NN703 and ipamorelin.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 18 | 8.51 | 9.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL298614 | — | — | 1 | 9.82 |
| CHEMBL60693 | — | — | 1 | 9.52 |
| CHEMBL13817 | IBUTAMOREN | 2.0 | 1 | 9.22 |
| CHEMBL57217 | — | — | 1 | 9.00 |
| CHEMBL299941 | — | — | 1 | 9.00 |
| CHEMBL58547 | IPAMORELIN | 2.0 | 1 | 8.89 |
| CHEMBL293129 | — | — | 1 | 8.74 |
| CHEMBL292684 | — | — | 1 | 8.70 |
| CHEMBL300562 | — | — | 1 | 8.57 |
| CHEMBL60750 | — | — | 1 | 8.40 |
| CHEMBL56515 | — | — | 1 | 8.30 |
| CHEMBL298844 | — | — | 1 | 8.22 |
| CHEMBL57805 | — | — | 1 | 8.00 |
| CHEMBL291312 | — | — | 1 | 8.00 |
| CHEMBL292932 | — | — | 1 | 7.85 |
| CHEMBL56573 | — | — | 1 | 7.77 |
| CHEMBL292931 | — | — | 1 | 7.68 |
| CHEMBL57927 | — | — | 1 | 7.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL298614 | — | EC50 | = | 0.15 | nM | 9.82 |
| CHEMBL60693 | — | EC50 | = | 0.3 | nM | 9.52 |
| CHEMBL13817 | IBUTAMOREN | EC50 | = | 0.6 | nM | 9.22 |
| CHEMBL57217 | — | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL299941 | — | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL58547 | IPAMORELIN | EC50 | = | 1.3 | nM | 8.89 |
| CHEMBL293129 | — | EC50 | = | 1.8 | nM | 8.74 |
| CHEMBL292684 | — | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL300562 | — | EC50 | = | 2.7 | nM | 8.57 |
| CHEMBL60750 | — | EC50 | = | 4.0 | nM | 8.40 |
| CHEMBL56515 | — | EC50 | = | 5.0 | nM | 8.30 |
| CHEMBL298844 | — | EC50 | = | 6.0 | nM | 8.22 |
| CHEMBL57805 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL291312 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL292932 | — | EC50 | = | 14.0 | nM | 7.85 |
| CHEMBL56573 | — | EC50 | = | 17.0 | nM | 7.77 |
| CHEMBL292931 | — | EC50 | = | 21.0 | nM | 7.68 |
| CHEMBL57927 | — | EC50 | = | 30.0 | nM | 7.52 |