Assay Detail
Functional
CHEMBL795132
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Effective concentration for ability to release growth hormone from rat pituitary cells
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Cell Type | Pituitary gland cell |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Rational design, discovery, and synthesis of a novel series of potent growth hormone secretagogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 15 | 8.13 | 10.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL322912 | — | — | 1 | 10.00 |
| CHEMBL106593 | PRALMORELIN | 2.0 | 1 | 9.70 |
| CHEMBL336400 | — | — | 1 | 9.00 |
| CHEMBL131555 | — | — | 1 | 9.00 |
| CHEMBL13817 | IBUTAMOREN | 2.0 | 1 | 8.89 |
| CHEMBL133848 | — | — | 1 | 8.74 |
| CHEMBL130229 | — | — | 1 | 8.52 |
| CHEMBL133571 | — | — | 1 | 8.00 |
| CHEMBL133238 | — | — | 1 | 8.00 |
| CHEMBL424271 | — | — | 1 | 8.00 |
| CHEMBL337618 | — | — | 1 | 7.00 |
| CHEMBL130000 | — | — | 1 | 7.00 |
| CHEMBL134172 | — | — | 1 | 6.00 |
| CHEMBL335174 | — | — | 1 | 6.00 |
| CHEMBL340075 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL322912 | — | EC50 | = | 0.1 | nM | 10.00 |
| CHEMBL106593 | PRALMORELIN | EC50 | = | 0.2 | nM | 9.70 |
| CHEMBL336400 | — | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL131555 | — | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL13817 | IBUTAMOREN | EC50 | = | 1.3 | nM | 8.89 |
| CHEMBL133848 | — | EC50 | = | 1.8 | nM | 8.74 |
| CHEMBL130229 | — | EC50 | = | 3.0 | nM | 8.52 |
| CHEMBL133571 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL133238 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL424271 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL337618 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL130000 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL134172 | — | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL335174 | — | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL340075 | — | EC50 | > | 1000.0 | nM | - |