Assay Detail
Binding
CHEMBL795959
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of binding to retinoid A receptor RAR beta
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Conformationally defined retinoic acid analogues. 4. Potential new agents for acute promyelocytic and juvenile myelomonocytic leukemias.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 7.67 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL38 | TRETINOIN | 4.0 | 1 | 8.30 |
| CHEMBL46398 | — | — | 1 | 8.22 |
| CHEMBL44478 | — | — | 1 | 8.10 |
| CHEMBL46397 | — | — | 1 | 7.31 |
| CHEMBL44582 | — | — | 1 | 6.43 |
| CHEMBL44979 | — | — | 1 | - |
| CHEMBL296193 | — | — | 1 | - |
| CHEMBL43833 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL38 | TRETINOIN | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL46398 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL44478 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL46397 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL44582 | — | IC50 | = | 371.0 | nM | 6.43 |
| CHEMBL44979 | — | IC50 | > | 2000.0 | nM | - |
| CHEMBL296193 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL43833 | — | IC50 | > | 1000.0 | nM | - |