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Assay Detail

CHEMBL795975

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
In vitro anti-oxytocic potency was evaluated in the absence of Mg2+
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Rattus norvegicus
Confidence 1 — Organism
Curated By Expert

Target

Rattus norvegicus (CHEMBL376)
Type ORGANISM
Organism Rattus norvegicus

Publication

Synthesis and some pharmacological properties of 18 potent O-alkyltyrosine-substituted antagonists of the vasopressor responses to arginine-vasopressin.
Manning M, Lammek B, Bankowski K, Seto J, Sawyer WH.
J Med Chem (1985) 28 : 1485 -1491
PubMed 4045923 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Kd 24 7.98 8.64

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2372285 1 8.64
CHEMBL2372304 1 8.59
CHEMBL2372297 1 8.43
CHEMBL2372287 1 8.43
CHEMBL2370969 1 8.36
CHEMBL2372303 1 8.13
CHEMBL2372315 1 8.13
CHEMBL2372312 1 8.12
CHEMBL2372299 1 8.12
CHEMBL2370976 1 8.02
CHEMBL2372295 1 7.98
CHEMBL2372309 1 7.96
CHEMBL2370971 1 7.93
CHEMBL2370972 1 7.88
CHEMBL2372324 1 7.85
CHEMBL2372293 1 7.82
CHEMBL2372311 1 7.77
CHEMBL2372296 1 7.73
CHEMBL2372307 1 7.72
CHEMBL2372308 1 7.72
CHEMBL2372298 1 7.61
CHEMBL2372306 1 7.55
CHEMBL2370569 1 7.55
CHEMBL2372301 1 7.50

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2372285 Kd = 2.291 nM 8.64
CHEMBL2372304 Kd = 2.57 nM 8.59
CHEMBL2372297 Kd = 3.715 nM 8.43
CHEMBL2372287 Kd = 3.715 nM 8.43
CHEMBL2370969 Kd = 4.365 nM 8.36
CHEMBL2372303 Kd = 7.413 nM 8.13
CHEMBL2372315 Kd = 7.413 nM 8.13
CHEMBL2372312 Kd = 7.586 nM 8.12
CHEMBL2372299 Kd = 7.586 nM 8.12
CHEMBL2370976 Kd = 9.55 nM 8.02
CHEMBL2372295 Kd = 10.47 nM 7.98
CHEMBL2372309 Kd = 10.96 nM 7.96
CHEMBL2370971 Kd = 11.75 nM 7.93
CHEMBL2370972 Kd = 13.18 nM 7.88
CHEMBL2372324 Kd = 14.13 nM 7.85
CHEMBL2372293 Kd = 15.14 nM 7.82
CHEMBL2372311 Kd = 16.98 nM 7.77
CHEMBL2372296 Kd = 18.62 nM 7.73
CHEMBL2372307 Kd = 19.05 nM 7.72
CHEMBL2372308 Kd = 19.05 nM 7.72
CHEMBL2372298 Kd = 24.55 nM 7.61
CHEMBL2372306 Kd = 28.18 nM 7.55
CHEMBL2370569 Kd = 28.18 nM 7.55
CHEMBL2372301 Kd = 31.62 nM 7.50