Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL795976

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
In vitro anti-oxytocic potency was evaluated in the presence of 0.5 mM of Mg2+
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Rattus norvegicus
Confidence 1 — Organism
Curated By Expert

Target

Rattus norvegicus (CHEMBL376)
Type ORGANISM
Organism Rattus norvegicus

Publication

Synthesis and some pharmacological properties of 18 potent O-alkyltyrosine-substituted antagonists of the vasopressor responses to arginine-vasopressin.
Manning M, Lammek B, Bankowski K, Seto J, Sawyer WH.
J Med Chem (1985) 28 : 1485 -1491
PubMed 4045923 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Kd 24 7.67 8.19

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2372309 1 8.19
CHEMBL2372308 1 8.10
CHEMBL2372307 1 8.10
CHEMBL2372297 1 8.00
CHEMBL2372304 1 7.93
CHEMBL2372296 1 7.93
CHEMBL2372287 1 7.90
CHEMBL2372295 1 7.89
CHEMBL2370969 1 7.87
CHEMBL2370569 1 7.81
CHEMBL2372312 1 7.71
CHEMBL2370971 1 7.69
CHEMBL2372301 1 7.67
CHEMBL2372285 1 7.66
CHEMBL2372293 1 7.57
CHEMBL2370972 1 7.53
CHEMBL2372303 1 7.43
CHEMBL2372324 1 7.41
CHEMBL2372311 1 7.36
CHEMBL2372299 1 7.35
CHEMBL2372306 1 7.35
CHEMBL2372298 1 7.24
CHEMBL2372315 1 7.24
CHEMBL2370976 1 7.06

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2372309 Kd = 6.457 nM 8.19
CHEMBL2372308 Kd = 7.943 nM 8.10
CHEMBL2372307 Kd = 7.943 nM 8.10
CHEMBL2372297 Kd = 10.0 nM 8.00
CHEMBL2372304 Kd = 11.75 nM 7.93
CHEMBL2372296 Kd = 11.75 nM 7.93
CHEMBL2372287 Kd = 12.59 nM 7.90
CHEMBL2372295 Kd = 12.88 nM 7.89
CHEMBL2370969 Kd = 13.49 nM 7.87
CHEMBL2370569 Kd = 15.49 nM 7.81
CHEMBL2372312 Kd = 19.5 nM 7.71
CHEMBL2370971 Kd = 20.42 nM 7.69
CHEMBL2372301 Kd = 21.38 nM 7.67
CHEMBL2372285 Kd = 21.88 nM 7.66
CHEMBL2372293 Kd = 26.92 nM 7.57
CHEMBL2370972 Kd = 29.51 nM 7.53
CHEMBL2372303 Kd = 37.15 nM 7.43
CHEMBL2372324 Kd = 38.9 nM 7.41
CHEMBL2372311 Kd = 43.65 nM 7.36
CHEMBL2372299 Kd = 44.67 nM 7.35
CHEMBL2372306 Kd = 44.67 nM 7.35
CHEMBL2372298 Kd = 57.54 nM 7.24
CHEMBL2372315 Kd = 57.54 nM 7.24
CHEMBL2370976 Kd = 87.1 nM 7.06