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Assay Detail

CHEMBL795977

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Functional
In vitro antiuterotonic activity in rat oxytocic bioassay in the absence of Mg2+
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Rattus norvegicus
Confidence 1 — Organism
Curated By Intermediate

Target

Rattus norvegicus (CHEMBL376)
Type ORGANISM
Organism Rattus norvegicus

Publication

Enhanced selectivity of oxytocin antagonists containing sarcosine in position 7.
Pavo I, Slaninova J, Klein U, Fahrenholz F.
J Med Chem (1994) 37 : 255 -259
PubMed 7507528 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Kd 15 8.09 8.60

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL330022 1 8.60
CHEMBL385604 1 8.59
CHEMBL314889 1 8.52
CHEMBL438387 1 8.40
CHEMBL87636 1 8.30
CHEMBL415230 1 8.30
CHEMBL426337 1 8.15
CHEMBL409030 1 8.13
CHEMBL265017 1 8.10
CHEMBL384292 1 8.00
CHEMBL414582 1 8.00
CHEMBL274397 1 7.90
CHEMBL411420 1 7.90
CHEMBL1793955 1 7.50
CHEMBL265264 1 6.95

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL330022 Kd = 2.512 nM 8.60
CHEMBL385604 Kd = 2.57 nM 8.59
CHEMBL314889 Kd = 3.02 nM 8.52
CHEMBL438387 Kd = 3.981 nM 8.40
CHEMBL87636 Kd = 5.012 nM 8.30
CHEMBL415230 Kd = 5.012 nM 8.30
CHEMBL426337 Kd = 7.079 nM 8.15
CHEMBL409030 Kd = 7.413 nM 8.13
CHEMBL265017 Kd = 7.943 nM 8.10
CHEMBL384292 Kd = 10.0 nM 8.00
CHEMBL414582 Kd = 10.0 nM 8.00
CHEMBL274397 Kd = 12.59 nM 7.90
CHEMBL411420 Kd = 12.59 nM 7.90
CHEMBL1793955 Kd = 31.62 nM 7.50
CHEMBL265264 Kd = 112.2 nM 6.95