Assay Detail
Functional
CHEMBL795978
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In vitro antiuterotonic activity in rat oxytocic bioassay in the presence of 1 mM Mg2+
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Enhanced selectivity of oxytocin antagonists containing sarcosine in position 7.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 8 | 7.83 | 8.20 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL330022 | — | — | 1 | 8.20 |
| CHEMBL415230 | — | — | 1 | 8.10 |
| CHEMBL414582 | — | — | 1 | 8.00 |
| CHEMBL87636 | — | — | 1 | 8.00 |
| CHEMBL411420 | — | — | 1 | 7.90 |
| CHEMBL407358 | — | — | 1 | 7.77 |
| CHEMBL274397 | — | — | 1 | 7.70 |
| CHEMBL1793955 | — | — | 1 | 7.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL330022 | — | Kd | = | 6.31 | nM | 8.20 |
| CHEMBL415230 | — | Kd | = | 7.943 | nM | 8.10 |
| CHEMBL414582 | — | Kd | = | 10.0 | nM | 8.00 |
| CHEMBL87636 | — | Kd | = | 10.0 | nM | 8.00 |
| CHEMBL411420 | — | Kd | = | 12.59 | nM | 7.90 |
| CHEMBL407358 | — | Kd | = | 16.98 | nM | 7.77 |
| CHEMBL274397 | — | Kd | = | 19.95 | nM | 7.70 |
| CHEMBL1793955 | — | Kd | = | 100.0 | nM | 7.00 |