Assay Detail
Functional
CHEMBL796063
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In vivo antiuterotonic activity in the rat uterotonic assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Enhanced selectivity of oxytocin antagonists containing sarcosine in position 7.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 10 | 7.27 | 7.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL265017 | — | — | 1 | 7.60 |
| CHEMBL274397 | — | — | 1 | 7.50 |
| CHEMBL330022 | — | — | 1 | 7.50 |
| CHEMBL415230 | — | — | 1 | 7.50 |
| CHEMBL414582 | — | — | 1 | 7.40 |
| CHEMBL87636 | — | — | 1 | 7.40 |
| CHEMBL438387 | — | — | 1 | 7.10 |
| CHEMBL411420 | — | — | 1 | 7.10 |
| CHEMBL384292 | — | — | 1 | 7.00 |
| CHEMBL1793955 | — | — | 1 | 6.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL265017 | — | Kd | = | 25.12 | nM | 7.60 |
| CHEMBL274397 | — | Kd | = | 31.62 | nM | 7.50 |
| CHEMBL330022 | — | Kd | = | 31.62 | nM | 7.50 |
| CHEMBL415230 | — | Kd | = | 31.62 | nM | 7.50 |
| CHEMBL414582 | — | Kd | = | 39.81 | nM | 7.40 |
| CHEMBL87636 | — | Kd | = | 39.81 | nM | 7.40 |
| CHEMBL438387 | — | Kd | = | 79.43 | nM | 7.10 |
| CHEMBL411420 | — | Kd | = | 79.43 | nM | 7.10 |
| CHEMBL384292 | — | Kd | = | 100.0 | nM | 7.00 |
| CHEMBL1793955 | — | Kd | = | 251.19 | nM | 6.60 |