Assay Detail
ADMET
CHEMBL796064
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vivo anti-vasopressor activity measured as the negative logarithm of the effective dose / the estimated volume of distribution (67 mL/kg)
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Rattus norvegicus |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Synthesis and some pharmacological properties of 18 potent O-alkyltyrosine-substituted antagonists of the vasopressor responses to arginine-vasopressin.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 24 | 8.33 | 8.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2372315 | — | — | 1 | 8.62 |
| CHEMBL2372308 | — | — | 1 | 8.57 |
| CHEMBL2372309 | — | — | 1 | 8.53 |
| CHEMBL2372312 | — | — | 1 | 8.47 |
| CHEMBL2372297 | — | — | 1 | 8.46 |
| CHEMBL2372293 | — | — | 1 | 8.46 |
| CHEMBL2372306 | — | — | 1 | 8.45 |
| CHEMBL2370971 | — | — | 1 | 8.44 |
| CHEMBL2372303 | — | — | 1 | 8.42 |
| CHEMBL2370569 | — | — | 1 | 8.41 |
| CHEMBL2372299 | — | — | 1 | 8.40 |
| CHEMBL2372287 | — | — | 1 | 8.36 |
| CHEMBL2372296 | — | — | 1 | 8.35 |
| CHEMBL2372307 | — | — | 1 | 8.33 |
| CHEMBL2370969 | — | — | 1 | 8.32 |
| CHEMBL2372311 | — | — | 1 | 8.31 |
| CHEMBL2370976 | — | — | 1 | 8.31 |
| CHEMBL2372304 | — | — | 1 | 8.29 |
| CHEMBL2372324 | — | — | 1 | 8.27 |
| CHEMBL2372295 | — | — | 1 | 8.19 |
| CHEMBL2370972 | — | — | 1 | 8.16 |
| CHEMBL2372285 | — | — | 1 | 8.07 |
| CHEMBL2372298 | — | — | 1 | 7.96 |
| CHEMBL2372301 | — | — | 1 | 7.84 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2372315 | — | Kd | = | 2.399 | nM | 8.62 |
| CHEMBL2372308 | — | Kd | = | 2.692 | nM | 8.57 |
| CHEMBL2372309 | — | Kd | = | 2.951 | nM | 8.53 |
| CHEMBL2372312 | — | Kd | = | 3.388 | nM | 8.47 |
| CHEMBL2372297 | — | Kd | = | 3.467 | nM | 8.46 |
| CHEMBL2372293 | — | Kd | = | 3.467 | nM | 8.46 |
| CHEMBL2372306 | — | Kd | = | 3.548 | nM | 8.45 |
| CHEMBL2370971 | — | Kd | = | 3.631 | nM | 8.44 |
| CHEMBL2372303 | — | Kd | = | 3.802 | nM | 8.42 |
| CHEMBL2370569 | — | Kd | = | 3.89 | nM | 8.41 |
| CHEMBL2372299 | — | Kd | = | 3.981 | nM | 8.40 |
| CHEMBL2372287 | — | Kd | = | 4.365 | nM | 8.36 |
| CHEMBL2372296 | — | Kd | = | 4.467 | nM | 8.35 |
| CHEMBL2372307 | — | Kd | = | 4.677 | nM | 8.33 |
| CHEMBL2370969 | — | Kd | = | 4.786 | nM | 8.32 |
| CHEMBL2372311 | — | Kd | = | 4.898 | nM | 8.31 |
| CHEMBL2370976 | — | Kd | = | 4.898 | nM | 8.31 |
| CHEMBL2372304 | — | Kd | = | 5.129 | nM | 8.29 |
| CHEMBL2372324 | — | Kd | = | 5.37 | nM | 8.27 |
| CHEMBL2372295 | — | Kd | = | 6.457 | nM | 8.19 |
| CHEMBL2370972 | — | Kd | = | 6.918 | nM | 8.16 |
| CHEMBL2372285 | — | Kd | = | 8.511 | nM | 8.07 |
| CHEMBL2372298 | — | Kd | = | 10.96 | nM | 7.96 |
| CHEMBL2372301 | — | Kd | = | 14.45 | nM | 7.84 |