Assay Detail
Functional
CHEMBL796074
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of pressor response to exogenous AVP in the pitched rat preparation
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Enhanced selectivity of oxytocin antagonists containing sarcosine in position 7.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 15 | 7.65 | 8.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL409030 | — | — | 1 | 8.62 |
| CHEMBL426337 | — | — | 1 | 8.35 |
| CHEMBL385604 | — | — | 1 | 8.35 |
| CHEMBL438387 | — | — | 1 | 8.00 |
| CHEMBL384292 | — | — | 1 | 8.00 |
| CHEMBL314889 | — | — | 1 | 7.96 |
| CHEMBL265264 | — | — | 1 | 7.93 |
| CHEMBL265017 | — | — | 1 | 7.80 |
| CHEMBL330022 | — | — | 1 | 7.70 |
| CHEMBL274397 | — | — | 1 | 7.50 |
| CHEMBL411420 | — | — | 1 | 7.50 |
| CHEMBL1793955 | — | — | 1 | 7.20 |
| CHEMBL414582 | — | — | 1 | 7.00 |
| CHEMBL87636 | — | — | 1 | 6.40 |
| CHEMBL415230 | — | — | 1 | 6.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL409030 | — | Kd | = | 2.399 | nM | 8.62 |
| CHEMBL426337 | — | Kd | = | 4.467 | nM | 8.35 |
| CHEMBL385604 | — | Kd | = | 4.467 | nM | 8.35 |
| CHEMBL438387 | — | Kd | = | 10.0 | nM | 8.00 |
| CHEMBL384292 | — | Kd | = | 10.0 | nM | 8.00 |
| CHEMBL314889 | — | Kd | = | 10.96 | nM | 7.96 |
| CHEMBL265264 | — | Kd | = | 11.75 | nM | 7.93 |
| CHEMBL265017 | — | Kd | = | 15.85 | nM | 7.80 |
| CHEMBL330022 | — | Kd | = | 19.95 | nM | 7.70 |
| CHEMBL274397 | — | Kd | = | 31.62 | nM | 7.50 |
| CHEMBL411420 | — | Kd | = | 31.62 | nM | 7.50 |
| CHEMBL1793955 | — | Kd | = | 63.1 | nM | 7.20 |
| CHEMBL414582 | — | Kd | = | 100.0 | nM | 7.00 |
| CHEMBL87636 | — | Kd | = | 398.11 | nM | 6.40 |
| CHEMBL415230 | — | Kd | = | 398.11 | nM | 6.40 |