Assay Detail
Functional
CHEMBL796079
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Negative logarithm of the concentration of compound required to reduce the response of EC50 dose of ANG II to the response to half the EC50 dose
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Importance of the N-terminal domain of the type II angiotensin antagonist sarmesin for receptor blockade.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 15 | 6.44 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL404594 | — | — | 1 | 8.10 |
| CHEMBL262260 | — | — | 1 | 7.50 |
| CHEMBL2372177 | — | — | 1 | 7.10 |
| CHEMBL407097 | — | — | 1 | 6.90 |
| CHEMBL262226 | — | — | 1 | 6.00 |
| CHEMBL268580 | — | — | 1 | 5.50 |
| CHEMBL408689 | — | — | 1 | 5.30 |
| CHEMBL2372178 | — | — | 1 | 5.10 |
| CHEMBL2372183 | — | — | 1 | - |
| CHEMBL261912 | — | — | 1 | - |
| CHEMBL265776 | — | — | 1 | - |
| CHEMBL285808 | — | — | 1 | - |
| CHEMBL412949 | — | — | 1 | - |
| CHEMBL30463 | — | — | 1 | - |
| CHEMBL2372176 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL404594 | — | Kd | = | 7.943 | nM | 8.10 |
| CHEMBL262260 | — | Kd | = | 31.62 | nM | 7.50 |
| CHEMBL2372177 | — | Kd | = | 79.43 | nM | 7.10 |
| CHEMBL407097 | — | Kd | = | 125.89 | nM | 6.90 |
| CHEMBL262226 | — | Kd | = | 1000.0 | nM | 6.00 |
| CHEMBL268580 | — | Kd | = | 3162.28 | nM | 5.50 |
| CHEMBL408689 | — | Kd | = | 5011.87 | nM | 5.30 |
| CHEMBL2372178 | — | Kd | = | 7943.28 | nM | 5.10 |
| CHEMBL2372183 | — | Kd | > | 10000.0 | nM | - |
| CHEMBL261912 | — | Kd | > | 1000.0 | nM | - |
| CHEMBL265776 | — | Kd | > | 10000.0 | nM | - |
| CHEMBL285808 | — | Kd | > | 10000.0 | nM | - |
| CHEMBL412949 | — | Kd | > | 10000.0 | nM | - |
| CHEMBL30463 | — | Kd | > | 1000.0 | nM | - |
| CHEMBL2372176 | — | Kd | > | 10000.0 | nM | - |