Assay Detail
Functional
CHEMBL796582
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Relaxation of endothelium denucleated strips of rat aorta precontracted with noradrenaline
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Aorta |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Water soluble furoxan derivatives as NO prodrugs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 17 | 6.47 | 8.39 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL143433 | — | — | 1 | 8.39 |
| CHEMBL143121 | — | — | 1 | 7.89 |
| CHEMBL136478 | SODIUM NITROPRUSSIDE | 4.0 | 1 | 7.67 |
| CHEMBL730 | NITROGLYCERIN | 4.0 | 1 | 7.65 |
| CHEMBL143095 | — | — | 1 | 7.52 |
| CHEMBL442486 | — | — | 1 | 7.28 |
| CHEMBL358626 | — | — | 1 | 7.25 |
| CHEMBL143301 | — | — | 1 | 7.08 |
| CHEMBL143521 | — | — | 1 | 7.00 |
| CHEMBL359264 | — | — | 1 | 5.99 |
| CHEMBL142771 | — | — | 1 | 5.91 |
| CHEMBL346206 | — | — | 1 | 5.81 |
| CHEMBL142959 | — | — | 1 | 5.46 |
| CHEMBL142651 | — | — | 1 | 5.13 |
| CHEMBL442487 | — | — | 1 | 4.84 |
| CHEMBL356730 | — | — | 1 | 4.82 |
| CHEMBL140522 | — | — | 1 | 4.32 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL143433 | — | EC50 | = | 4.1 | nM | 8.39 |
| CHEMBL143121 | — | EC50 | = | 13.0 | nM | 7.89 |
| CHEMBL136478 | SODIUM NITROPRUSSIDE | EC50 | = | 21.5 | nM | 7.67 |
| CHEMBL730 | NITROGLYCERIN | EC50 | = | 22.4 | nM | 7.65 |
| CHEMBL143095 | — | EC50 | = | 30.0 | nM | 7.52 |
| CHEMBL442486 | — | EC50 | = | 52.0 | nM | 7.28 |
| CHEMBL358626 | — | EC50 | = | 55.7 | nM | 7.25 |
| CHEMBL143301 | — | EC50 | = | 82.6 | nM | 7.08 |
| CHEMBL143521 | — | EC50 | = | 101.0 | nM | 7.00 |
| CHEMBL359264 | — | EC50 | = | 1030.0 | nM | 5.99 |
| CHEMBL142771 | — | EC50 | = | 1230.0 | nM | 5.91 |
| CHEMBL346206 | — | EC50 | = | 1550.0 | nM | 5.81 |
| CHEMBL142959 | — | EC50 | = | 3480.0 | nM | 5.46 |
| CHEMBL142651 | — | EC50 | = | 7350.0 | nM | 5.13 |
| CHEMBL442487 | — | EC50 | = | 14300.0 | nM | 4.84 |
| CHEMBL356730 | — | EC50 | = | 15200.0 | nM | 4.82 |
| CHEMBL140522 | — | EC50 | = | 48100.0 | nM | 4.32 |