Assay Detail
Functional
CHEMBL796583
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Relaxation of endothelium denucleated strips of rat aorta precontracted with noradrenaline in presence of 10 uM HbO2
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Aorta |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Water soluble furoxan derivatives as NO prodrugs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 16 | 5.95 | 7.34 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL143121 | — | — | 1 | 7.34 |
| CHEMBL143433 | — | — | 1 | 7.32 |
| CHEMBL136478 | SODIUM NITROPRUSSIDE | 4.0 | 1 | 7.32 |
| CHEMBL143095 | — | — | 1 | 6.89 |
| CHEMBL358626 | — | — | 1 | 6.48 |
| CHEMBL442486 | — | — | 1 | 6.46 |
| CHEMBL143521 | — | — | 1 | 6.37 |
| CHEMBL143301 | — | — | 1 | 6.00 |
| CHEMBL142771 | — | — | 1 | 5.65 |
| CHEMBL359264 | — | — | 1 | 5.44 |
| CHEMBL346206 | — | — | 1 | 4.94 |
| CHEMBL142959 | — | — | 1 | 4.82 |
| CHEMBL142651 | — | — | 1 | 4.17 |
| CHEMBL356730 | — | — | 1 | 4.11 |
| CHEMBL442487 | — | — | 1 | - |
| CHEMBL140522 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL143121 | — | EC50 | = | 46.0 | nM | 7.34 |
| CHEMBL143433 | — | EC50 | = | 48.0 | nM | 7.32 |
| CHEMBL136478 | SODIUM NITROPRUSSIDE | EC50 | = | 48.1 | nM | 7.32 |
| CHEMBL143095 | — | EC50 | = | 130.0 | nM | 6.89 |
| CHEMBL358626 | — | EC50 | = | 330.0 | nM | 6.48 |
| CHEMBL442486 | — | EC50 | = | 350.0 | nM | 6.46 |
| CHEMBL143521 | — | EC50 | = | 430.0 | nM | 6.37 |
| CHEMBL143301 | — | EC50 | = | 1010.0 | nM | 6.00 |
| CHEMBL142771 | — | EC50 | = | 2220.0 | nM | 5.65 |
| CHEMBL359264 | — | EC50 | = | 3630.0 | nM | 5.44 |
| CHEMBL346206 | — | EC50 | = | 11500.0 | nM | 4.94 |
| CHEMBL142959 | — | EC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL142651 | — | EC50 | = | 68000.0 | nM | 4.17 |
| CHEMBL356730 | — | EC50 | = | 78000.0 | nM | 4.11 |
| CHEMBL442487 | — | EC50 | = | 124400.0 | nM | - |
| CHEMBL140522 | — | EC50 | = | 123800.0 | nM | - |