Assay Detail
Functional
CHEMBL796595
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of methoxamine-contracted rat aorta (Vasorelaxant potency)
7
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Aorta |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
A novel anti-ischemic ATP-sensitive potassium channel (K(ATP)) opener without vasorelaxation: N-(6-aminobenzopyranyl)-N'-benzyl-N' '-cyanoguanidine analogue.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 4.95 | 5.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL44340 | — | — | 1 | 5.50 |
| CHEMBL3350273 | — | — | 2 | 5.14 |
| CHEMBL2111896 | — | — | 1 | 4.90 |
| CHEMBL135817 | — | — | 1 | 4.79 |
| CHEMBL2112716 | — | — | 1 | 4.76 |
| CHEMBL2112723 | — | — | 1 | 4.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL44340 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL3350273 | — | IC50 | = | 7300.0 | nM | 5.14 |
| CHEMBL3350273 | — | IC50 | = | 9800.0 | nM | 5.01 |
| CHEMBL2111896 | — | IC50 | = | 12600.0 | nM | 4.90 |
| CHEMBL135817 | — | IC50 | = | 16100.0 | nM | 4.79 |
| CHEMBL2112716 | — | IC50 | = | 17500.0 | nM | 4.76 |
| CHEMBL2112723 | — | IC50 | = | 30500.0 | nM | 4.52 |