Assay Detail
Functional
CHEMBL796736
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Inhibitory concentration for half-maximal displacement of 1.0 nM [3H]ADTN specific binding from rat striatal membranes using 10E-5 sulpiride
11
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Subcellular | Membrane |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Synthesis and dopaminergic properties of some exo- and endo-2-aminobenzonorbornenes designed as rigid analogue of dopamine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 7.52 | 8.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL53 | APOMORPHINE | 4.0 | 1 | 8.85 |
| CHEMBL26736 | — | — | 1 | 8.77 |
| CHEMBL59 | DOPAMINE | 4.0 | 1 | 8.68 |
| CHEMBL334191 | — | — | 2 | 8.11 |
| CHEMBL121070 | — | — | 1 | 7.48 |
| CHEMBL331550 | — | — | 1 | 7.09 |
| CHEMBL332459 | — | — | 2 | 7.08 |
| CHEMBL122958 | — | — | 2 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL53 | APOMORPHINE | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL26736 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL59 | DOPAMINE | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL334191 | — | IC50 | = | 7.8 | nM | 8.11 |
| CHEMBL121070 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL331550 | — | IC50 | = | 81.0 | nM | 7.09 |
| CHEMBL332459 | — | IC50 | = | 84.0 | nM | 7.08 |
| CHEMBL334191 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL332459 | — | IC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL122958 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL122958 | — | IC50 | > | 10000.0 | nM | - |