Assay Detail
Functional
CHEMBL796737
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Inhibitory concentration half-maximal displacement of 1.0 nM [3H]NPA specific binding from rat striatal membranes using 10e-5 (+/-)ADTN
11
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Subcellular | Membrane |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Synthesis and dopaminergic properties of some exo- and endo-2-aminobenzonorbornenes designed as rigid analogue of dopamine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 7.04 | 8.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL53 | APOMORPHINE | 4.0 | 1 | 8.74 |
| CHEMBL59 | DOPAMINE | 4.0 | 1 | 8.70 |
| CHEMBL26736 | — | — | 1 | 8.52 |
| CHEMBL334191 | — | — | 2 | 6.96 |
| CHEMBL121070 | — | — | 1 | 6.52 |
| CHEMBL331550 | — | — | 1 | 6.27 |
| CHEMBL332459 | — | — | 2 | 6.21 |
| CHEMBL122958 | — | — | 2 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL53 | APOMORPHINE | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL59 | DOPAMINE | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL26736 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL334191 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL121070 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL334191 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL331550 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL332459 | — | IC50 | = | 610.0 | nM | 6.21 |
| CHEMBL332459 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL122958 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL122958 | — | IC50 | > | 10000.0 | nM | - |