Assay Detail
Functional
CHEMBL796744
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Inhibition constant on radiolabeled [125I]FIDA1 binding to rat striatal membranes
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Striatum |
| Subcellular | Membrane |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Fluorinated and iodinated dopamine agents: D2 imaging agents for PET and SPECT.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 9.75 | 10.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL8946 | ETICLOPRIDE | 2.0 | 1 | 10.85 |
| CHEMBL8809 | RACLOPRIDE | 2.0 | 1 | 8.64 |
| CHEMBL27 | PROPRANOLOL | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL8946 | ETICLOPRIDE | Ki | = | 0.014 | nM | 10.85 |
| CHEMBL8809 | RACLOPRIDE | Ki | = | 2.31 | nM | 8.64 |
| CHEMBL27 | PROPRANOLOL | Ki | > | 10000.0 | nM | - |