Assay Detail

CHEMBL796745

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Functional

Inhibition constant on radiolabeled [125I]FIDA2 binding to rat striatal membranes

ChEMBL ↗

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Target

Rattus norvegicus (CHEMBL376) ↗

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Rattus norvegicus (CHEMBL376) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Rattus norvegicus

CHEMBL376

Anchored from Assay target.

Protein identity Rattus norvegicus

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Rattus norvegicus
Tissue	Striatum
Subcellular	Membrane
Confidence	1 — Organism
Curated By	Intermediate

Target

Rattus norvegicus (CHEMBL376) ↗

Type	ORGANISM
Organism	Rattus norvegicus

Publication

Fluorinated and iodinated dopamine agents: D2 imaging agents for PET and SPECT.

Chumpradit S, Kung MP, Billings J, Mach R, Kung HF.
J Med Chem (1993) 36 : 221 -228
PubMed 8093734 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
Ki	2	9.26	10.22

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL8946	ETICLOPRIDE	2.0	1	10.22
CHEMBL8809	RACLOPRIDE	2.0	1	8.30

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL8946	ETICLOPRIDE	Ki	=	0.06	nM	10.22
CHEMBL8809	RACLOPRIDE	Ki	=	5.0	nM	8.30