Assay Detail
Functional
CHEMBL796884
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Myorelaxant activity in rat aorta in the presence 80 mM KCL.
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Aorta |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Original 2-alkylamino-6-halogenoquinazolin-4(3H)-ones and K(ATP) channel activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 4.61 | 4.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1159 | PINACIDIL ANHYDROUS | 4.0 | 1 | 4.80 |
| CHEMBL420420 | — | — | 1 | 4.74 |
| CHEMBL85853 | — | — | 1 | 4.46 |
| CHEMBL87565 | — | — | 1 | 4.43 |
| CHEMBL181 | DIAZOXIDE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1159 | PINACIDIL ANHYDROUS | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL420420 | — | IC50 | = | 18100.0 | nM | 4.74 |
| CHEMBL85853 | — | IC50 | = | 34300.0 | nM | 4.46 |
| CHEMBL87565 | — | IC50 | = | 37200.0 | nM | 4.43 |
| CHEMBL181 | DIAZOXIDE | IC50 | > | 300000.0 | nM | - |