Assay Detail
Functional
CHEMBL796887
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In vitro inhibition of 30 mM KCl-induced contraction of rat aorta rings.
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Aorta |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Original 2-alkylamino-6-halogenoquinazolin-4(3H)-ones and K(ATP) channel activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 5.20 | 6.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1159 | PINACIDIL ANHYDROUS | 4.0 | 1 | 6.30 |
| CHEMBL420421 | — | — | 1 | 5.85 |
| CHEMBL2114213 | — | — | 1 | 5.77 |
| CHEMBL87689 | — | — | 1 | 5.68 |
| CHEMBL87944 | — | — | 1 | 5.66 |
| CHEMBL312833 | — | — | 1 | 5.55 |
| CHEMBL86644 | — | — | 1 | 5.50 |
| CHEMBL315543 | — | — | 1 | 5.41 |
| CHEMBL87720 | — | — | 1 | 5.39 |
| CHEMBL420420 | — | — | 1 | 5.25 |
| CHEMBL314135 | — | — | 1 | 5.12 |
| CHEMBL87681 | — | — | 1 | 5.05 |
| CHEMBL87565 | — | — | 1 | 4.92 |
| CHEMBL315470 | — | — | 1 | 4.91 |
| CHEMBL83630 | — | — | 1 | 4.86 |
| CHEMBL86591 | — | — | 1 | 4.79 |
| CHEMBL85853 | — | — | 1 | 4.76 |
| CHEMBL181 | DIAZOXIDE | 4.0 | 1 | 4.71 |
| CHEMBL87756 | — | — | 1 | 4.36 |
| CHEMBL82815 | — | — | 1 | 4.17 |
| CHEMBL32111 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1159 | PINACIDIL ANHYDROUS | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL420421 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL2114213 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL87689 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL87944 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL312833 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL86644 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL315543 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL87720 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL420420 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL314135 | — | IC50 | = | 7600.0 | nM | 5.12 |
| CHEMBL87681 | — | IC50 | = | 8900.0 | nM | 5.05 |
| CHEMBL87565 | — | IC50 | = | 12100.0 | nM | 4.92 |
| CHEMBL315470 | — | IC50 | = | 12400.0 | nM | 4.91 |
| CHEMBL83630 | — | IC50 | = | 13800.0 | nM | 4.86 |
| CHEMBL86591 | — | IC50 | = | 16300.0 | nM | 4.79 |
| CHEMBL85853 | — | IC50 | = | 17300.0 | nM | 4.76 |
| CHEMBL181 | DIAZOXIDE | IC50 | = | 19300.0 | nM | 4.71 |
| CHEMBL87756 | — | IC50 | = | 43700.0 | nM | 4.36 |
| CHEMBL82815 | — | IC50 | = | 67300.0 | nM | 4.17 |
| CHEMBL32111 | — | IC50 | = | 154000.0 | nM | - |