Assay Detail
Functional
CHEMBL796888
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Tested for the vasorelaxant potency in methoxamine contracted rat aorta
42
Total Activities
41
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Aorta |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Cardioselective anti-ischemic ATP-sensitive potassium channel openers. 3. Structure-activity studies on benzopyranyl cyanoguanidines: modification of the cyanoguanidine portion.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 42 | 5.59 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL325134 | — | — | 1 | 7.52 |
| CHEMBL49035 | CROMAKALIM | 2.0 | 1 | 7.50 |
| CHEMBL417465 | — | — | 1 | 6.70 |
| CHEMBL324661 | — | — | 1 | 6.52 |
| CHEMBL321469 | — | — | 1 | 6.36 |
| CHEMBL325759 | — | — | 1 | 6.30 |
| CHEMBL111588 | — | — | 1 | 6.30 |
| CHEMBL322963 | — | — | 1 | 6.22 |
| CHEMBL324908 | — | — | 1 | 6.17 |
| CHEMBL300166 | — | — | 1 | 6.10 |
| CHEMBL109856 | — | — | 1 | 6.00 |
| CHEMBL58703 | — | — | 2 | 5.89 |
| CHEMBL326447 | — | — | 1 | 5.85 |
| CHEMBL110080 | — | — | 1 | 5.80 |
| CHEMBL111758 | — | — | 1 | 5.78 |
| CHEMBL44340 | — | — | 1 | 5.75 |
| CHEMBL321004 | — | — | 1 | 5.75 |
| CHEMBL420118 | — | — | 1 | 5.66 |
| CHEMBL111429 | — | — | 1 | 5.62 |
| CHEMBL109855 | — | — | 1 | 5.57 |
| CHEMBL423143 | — | — | 1 | 5.46 |
| CHEMBL109973 | — | — | 1 | 5.39 |
| CHEMBL111781 | — | — | 1 | 5.34 |
| CHEMBL326135 | — | — | 1 | 5.31 |
| CHEMBL111693 | — | — | 1 | 5.29 |
| CHEMBL111380 | — | — | 1 | 5.25 |
| CHEMBL321237 | — | — | 1 | 5.20 |
| CHEMBL320930 | — | — | 1 | 5.09 |
| CHEMBL111004 | — | — | 1 | 5.08 |
| CHEMBL113533 | — | — | 1 | 5.07 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL325134 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL49035 | CROMAKALIM | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL417465 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL324661 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL321469 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL325759 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL111588 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL322963 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL324908 | — | IC50 | = | 670.0 | nM | 6.17 |
| CHEMBL300166 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL109856 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL58703 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL58703 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL326447 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL110080 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL111758 | — | IC50 | = | 1660.0 | nM | 5.78 |
| CHEMBL44340 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL321004 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL420118 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL111429 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL109855 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL423143 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL109973 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL111781 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL326135 | — | IC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL111693 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL111380 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL321237 | — | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL320930 | — | IC50 | = | 8100.0 | nM | 5.09 |
| CHEMBL111004 | — | IC50 | = | 8400.0 | nM | 5.08 |
| CHEMBL113533 | — | IC50 | = | 8500.0 | nM | 5.07 |
| CHEMBL111398 | — | IC50 | = | 18400.0 | nM | 4.74 |
| CHEMBL110260 | — | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL325784 | — | IC50 | = | 23700.0 | nM | 4.62 |
| CHEMBL320348 | — | IC50 | = | 29800.0 | nM | 4.53 |
| CHEMBL111193 | — | IC50 | = | 32500.0 | nM | 4.49 |
| CHEMBL326674 | — | IC50 | = | 33100.0 | nM | 4.48 |
| CHEMBL111002 | — | IC50 | = | 41000.0 | nM | 4.39 |
| CHEMBL111581 | — | IC50 | = | 41300.0 | nM | 4.38 |
| CHEMBL111418 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL321677 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL111267 | — | IC50 | > | 100000.0 | nM | - |