Assay Detail
Functional
CHEMBL796889
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Vasorelaxant potency determined by measurement of IC50 value for relaxation of rat aorta precontracted with methoxamine
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Aorta |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Cardioselective antiischemic ATP-sensitive potassium channel (KATP) openers. 5. Identification of 4-(N-aryl)-substituted benzopyran derivatives with high selectivity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 31 | 4.97 | 7.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL49035 | CROMAKALIM | 2.0 | 1 | 7.50 |
| CHEMBL116122 | — | — | 1 | 5.92 |
| CHEMBL44340 | — | — | 1 | 5.75 |
| CHEMBL114873 | — | — | 1 | 5.66 |
| CHEMBL114157 | — | — | 1 | 4.92 |
| CHEMBL114047 | — | — | 1 | 4.57 |
| CHEMBL324617 | — | — | 1 | 4.57 |
| CHEMBL326674 | — | — | 1 | 4.48 |
| CHEMBL116349 | — | — | 1 | 4.37 |
| CHEMBL432420 | — | — | 1 | 4.33 |
| CHEMBL325866 | — | — | 1 | 4.27 |
| CHEMBL115879 | — | — | 1 | 4.23 |
| CHEMBL116218 | — | — | 1 | 4.08 |
| CHEMBL327019 | — | — | 1 | - |
| CHEMBL322767 | — | — | 1 | - |
| CHEMBL428891 | — | — | 1 | - |
| CHEMBL268271 | — | — | 1 | - |
| CHEMBL11859 | — | — | 1 | - |
| CHEMBL113889 | — | — | 1 | - |
| CHEMBL115839 | — | — | 1 | - |
| CHEMBL324111 | — | — | 1 | - |
| CHEMBL418850 | — | — | 1 | - |
| CHEMBL114087 | — | — | 1 | - |
| CHEMBL114482 | — | — | 1 | - |
| CHEMBL114097 | — | — | 1 | - |
| CHEMBL2111755 | — | — | 1 | - |
| CHEMBL114931 | — | — | 1 | - |
| CHEMBL11594 | BMS-191095 | — | 1 | - |
| CHEMBL332038 | — | — | 1 | - |
| CHEMBL116459 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL49035 | CROMAKALIM | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL116122 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL44340 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL114873 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL114157 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL114047 | — | IC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL324617 | — | IC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL326674 | — | IC50 | = | 33000.0 | nM | 4.48 |
| CHEMBL116349 | — | IC50 | = | 43000.0 | nM | 4.37 |
| CHEMBL432420 | — | IC50 | = | 47000.0 | nM | 4.33 |
| CHEMBL325866 | — | IC50 | = | 54000.0 | nM | 4.27 |
| CHEMBL115879 | — | IC50 | = | 59000.0 | nM | 4.23 |
| CHEMBL116218 | — | IC50 | = | 84000.0 | nM | 4.08 |
| CHEMBL325956 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL327019 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL322767 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL428891 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL268271 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL11859 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL113889 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL115839 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL324111 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL418850 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL114087 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL114482 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL114097 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL2111755 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL114931 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL11594 | BMS-191095 | IC50 | > | 30000.0 | nM | - |
| CHEMBL332038 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL116459 | — | IC50 | > | 30000.0 | nM | - |